The Sansoz Research Laboratory advances fundamental understanding of plastic deformation and failure in nanoscale and ultrafine-grained materials. Using micro and nanotechnologies, large-scale atomistic simulation, and materials theory, we investigate how complex interfacial chemistries and nanoscale microstructures govern strength, ductility, and thermal stability at the smallest scales. These discoveries support the development of next-generation structural materials for extreme environments, spanning across energy, aerospace, electronics, and modern computing.